Open AccessEFFECTS OF EXPLOSIVE BRAIN DEATH ON CYTOKINE ACTIVATION OF PERIPHERAL ORGANS IN THE RAT1
Author(s) -
Moriatsu Takada,
Kari Nadeau,
Wayne W. Hancock,
Harald S. Mackenzie,
Gray D. Shaw,
Ana Marie Waaga,
Anil Chandraker,
Mohamed H. Sayegh,
Nicholas L. Tilney
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199806270-00001
Subject(s) - proinflammatory cytokine , medicine , immunology , antigen , immune system , immunogenicity , inflammation , biology
The success rate of transplanted organs from brain-dead cadaver donors is consistently inferior to that of living sources. As cadaver and living unrelated donors are equally genetically disparate with a given recipient, the difference must lie within the donor himself and/or the effects of organ preservation and storage. We have hypothesized that irreversible central nervous system injury may up-regulate proinflammatory mediators and cell surface molecules in peripheral organs to be engrafted, making them more prone to host inflammatory and immunological responses.