Open AccessEARLY LOSS OF RENAL TRANSPLANTS IN PATIENTS WITH THROMBOPHILIA
Author(s) -
Michael Fischereder,
Peter Göhring,
H. Schneeberger,
Peter Lohse,
K. von Appen,
W. Samtleben,
Detlef Schlöndorff,
W. Land
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199804150-00013
Subject(s) - thrombophilia , medicine , protein s deficiency , factor v leiden , lupus anticoagulant , transplantation , protein c deficiency , thrombosis , protein s , surgery , activated protein c resistance , gastroenterology , venous thrombosis
We considered the possibility that thrombophilia may propagate graft thrombosis and therefore we evaluated the protein C system, which is a natural anticoagulant. Potential alterations in this system include protein C or protein S deficiency, inhibition through a lupus anticoagulant (LA), or a resistance to activated protein C due to the factor V Leiden (FVL) mutation.