Open AccessAPOPTOSIS AND INCREASED EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN HUMAN ALLOGRAFT REJECTION1
Author(s) -
Matthias Szabolcs,
Stefano Ravalli,
Oktavijan P. Minanov,
Robert R. Sciacca,
Robert E. Michler,
Paul J. Can
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199803270-00007
Subject(s) - nitrotyrosine , myocyte , peroxynitrite , apoptosis , cardiac myocyte , nitric oxide synthase , transplantation , cd68 , pathology , biology , nitric oxide , medicine , immunology , endocrinology , immunohistochemistry , enzyme , biochemistry , superoxide
The mechanisms of myocyte death during cardiac allograft rejection are incompletely understood. In a previous study using a rat heterotopic cardiac allograft model, we showed that cardiac myocyte apoptosis, inducible nitric oxide synthase (iNOS) mRNA, protein and enzyme activity, and nitrotyrosine increased simultaneously during cardiac allograft rejection. This study was designed to investigate whether apoptosis and expression of iNOS occur in human cardiac allograft rejection.