Open AccessA SIGNIFICANT REDUCTION OF MACROPHAGES EXPRESSING INDUCIBLE NITRIC OXIDE SYNTHASE IN RAT HEPATIC ALLOGRAFTS PRETREATED WITH DONOR-SPECIFIC BLOOD
Author(s) -
Osamu Ichiguchi,
Yasuo Yamaguchi,
Mataro Goto,
Fujio Matsumura,
Nobutomo Miyanari,
Eiji Akizuki,
Takanori Matsuda,
Kazutoshi Okabe,
Jian Liang,
Hajime Ohshiro,
Katsutaka Mori,
Michio Ogawa
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199803270-00003
Subject(s) - nitric oxide synthase , nitric oxide , immunostaining , transplantation , macrophage , spleen , western blot , tumor necrosis factor alpha , immunology , liver transplantation , microbiology and biotechnology , chemistry , medicine , biology , immunohistochemistry , endocrinology , biochemistry , in vitro , gene
A single intravenous injection of donor-specific blood (DST) 7 days before transplantation significantly prolongs survival of hepatic allografts from fully allogeneic ACI(RT1a)-->LEW(RT1(1)) rats. The aim of this study was to investigate the kinetics of nitric oxide synthesis by macrophages in rat hepatic allografts treated with DST.