Open AccessFAS LIGAND GENE TRANSFER TO RENAL ALLOGRAFTS IN RATS
Author(s) -
Kim Swenson,
Bibo Ke,
Tao Wang,
Jay S. Markowitz,
Melinda A. Maggard,
Gerald S. Spear,
David K. Imagawa,
John A. Goss,
Ronald W. Busuttil,
Philip Seu
Publication year - 1998
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199801270-00002
Subject(s) - fas ligand , gene transfer , ligand (biochemistry) , gene , medicine , biology , immunology , chemistry , genetics , receptor , apoptosis , programmed cell death
Fas ligand (FasL) induces apoptosis of cells bearing its receptor Fas, and has been shown to be important in T-cell development and regulation and in immune privilege. We hypothesized that FasL expression by renal allografts might provide protection from rejection.