Open AccessEFFECTS OF PRAVASTATIN ON CHRONIC REJECTION OF RAT CARDIAC ALLOGRAFTS1,2
Author(s) -
Melinda A. Maggard,
Bibo Ke,
Tao Wang,
Fady M. Kaldas,
Philip Seu,
Ronald W. Busuttil,
David K. Imagawa
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199801270-00001
Subject(s) - pravastatin , medicine , cellular infiltration , transplantation , fibronectin , heart transplantation , pathology , immunology , extracellular matrix , inflammation , biology , biochemistry , cholesterol
Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, inhibits coronary transplant vasculopathy in the clinical setting. To further delineate the immune modulatory effect of this agent, it was tested in a rat cardiac transplant model of chronic rejection.