Open AccessAN EXPERIMENTAL MODEL OF CHRONIC RENAL ALLOGRAFT REJECTION IN THE RAT USING TRIPLE DRUG IMMUNOSUPPRESSION1
Author(s) -
Anu Soots,
Irmeli Lautenschlager,
Leena Krogerus,
O. Saarinen,
J Ahonen
Publication year - 1998
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199801150-00009
Subject(s) - medicine , azathioprine , methylprednisolone , transplantation , immunosuppression , immunosuppressive drug , inflammation , urology , kidney transplantation , transplant rejection , kidney , surgery , pathology , disease
Chronic rejection is a major problem in renal transplantation. Various experimental models have been developed to study vasculopathy of chronic rejection. However, animal models resembling the clinical situation of renal transplantation with combination therapy of basic immunosuppression are not available. The aim of this study was to find an experimental model of a donor-recipient rat strain combination that, under triple drug immunosuppressive treatment (methylprednisolone, cyclosporine, and azathioprine), would develop chronic rejection within a few weeks.