Open AccessINDUCTION OF TOLERANCE WITH NONDEPLETING ANTI-CD4 MONOCLONAL ANTIBODIES IS ASSOCIATED WITH DOWN-REGULATION OF TH2 CYTOKINES1
Author(s) -
Karren M. Plain,
L. Fava,
Austin Spinelli,
Xiaofu He,
Juchuan Chen,
Rochelle Boyd,
Cassandra L. Davidson,
Bruce M. Hall
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199712150-00009
Subject(s) - lymphotoxin , cd8 , monoclonal antibody , immunology , granzyme b , cytokine , perforin , biology , t cell , microbiology and biotechnology , tumor necrosis factor alpha , interleukin 4 , antibody , immune system
Induction of tolerance with anti-CD4 has mainly focused on monoclonal antibodies (mAbs) that deplete CD4+ T cells. In this study, the mechanisms by which nondepleting anti-CD4 mAbs induce tolerance in the Dark Agouti to PVG rat heart graft model were examined.