Open AccessIMMUNE SUPPRESSION BY LYSOSOMOTROPIC AMINES AND CYCLOSPORINE ON T-CELL RESPONSES TO MINOR AND MAJOR HISTOCOMPATIBILITY ANTIGENS
Author(s) -
Kirk R. Schultz,
Sharon Bader,
David L. Nelson,
Ming D. Wang,
Kent T. HayGlass
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199710150-00019
Subject(s) - immune system , major histocompatibility complex , immunology , t cell , cytotoxic t cell , antigen , chloroquine , antigen presentation , hydroxychloroquine , immunosuppression , biology , chemistry , pharmacology , medicine , in vitro , biochemistry , disease , malaria , covid-19 , infectious disease (medical specialty)
Using murine models, we have shown that the lysosomotropic amine, chloroquine, is effective in the prevention of graft-versus-host disease (GVHD) mediated by donor T cells reactive with recipient minor histocompatibility antigens (MiHCs). Because lysosomotropic amines can suppress major histocompatibility complex (MHC) class II antigen presentation, their mechanism of action is potentially different from current immune suppressant drugs used to control GVHD such as cyclosporine.