Open AccessA NONVIRAL VECTOR SYSTEM FOR EFFICIENT GENE TRANSFER TO CORNEAL ENDOTHELIAL CELLS VIA MEMBRANE INTEGRINS1
Author(s) -
Lorna Shewring,
Louise Collins,
Susan Lightman,
Stephen L. Hart,
Kenth Gustafsson,
John W. Fabre
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199709150-00018
Subject(s) - transfection , microbiology and biotechnology , corneal endothelium , biology , reporter gene , chemistry , endothelium , gene , biochemistry , gene expression , endocrinology
Genetic manipulation of allografts to suppress their ability to induce rejection is a promising approach for controlling rejection responses. A key to this approach is the development of appropriate DNA vectors. We are developing nonviral DNA vector systems based on synthetic peptides containing an integrin-binding segment for cellular targeting and a polylysine segment for DNA binding.