Open AccessUSE OF AEROSOLIZED COLISTIN SODIUM IN CYSTIC FIBROSIS PATIENTS AWAITING LUNG TRANSPLANTATION
Author(s) -
Gerene Bauldoff,
David R. Nunley,
Jan D. Manzetti,
James H. Dauber,
Robert J. Keenan
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199709150-00015
Subject(s) - colistin , cystic fibrosis , lung transplantation , antibiotics , transplantation , aerosolization , medicine , pseudomonas aeruginosa , sputum , polymyxin , microbiology and biotechnology , immunosuppression , antimicrobial , biology , bacteria , inhalation , pathology , anesthesia , tuberculosis , genetics
In patients with cystic fibrosis (CF) who are awaiting lung transplant, prolonged exposure to systemic antibiotics has frequently led to airway colonization with resistant isolates of Pseudomonas. This resistance limits the arsenal of effective antimicrobials available for infections after the initiation of immunosuppression and has been considered a theoretical deterrent to lung transplantation.