Open AccessEFFECTS OF LEFLUNOMIDE AND DEOXYSPERGUALIN IN THE GUINEA PIG???RAT CARDIAC MODEL OF DELAYED XENOGRAFT REJECTION
Author(s) -
Wayne W. Hancock,
Takashi Miyatake,
Nozomi Koyamada,
Jean P. Kut,
Miguel P. Soares,
Mary E. Russell,
Fritz H. Bach,
Mohamed H. Sayegh
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199709150-00006
Subject(s) - leflunomide , chemokine , antibody , guinea pig , infiltration (hvac) , immunology , cellular infiltration , medicine , monoclonal antibody , immune system , inflammation , thermodynamics , physics , methotrexate
If complement (C) activation is prevented or the host is C depleted, discordant vascularized xenografts undergo delayed xenograft rejection (DXR), characterized by graft infiltration by macrophages (MO) and natural killer (NK) cells, endothelial cell activation, and widespread fibrin deposition. Given a lack of effect of T cell-directed therapies on development of DXR, we evaluated two novel agents, 15-deoxyspergualin (DSG) and leflunomide (LEF), with reported anti-B-cell and/or anti-MO actions.