Open AccessHETEROGENEITY OF HUMAN ANTI-PIG NATURAL ANTIBODIES CROSS-REACTIVE WITH THE GAL(??1,3)GALACTOSE EPITOPE1
Author(s) -
Isabel M. McMorrow,
Christopher A. Comrack,
David H. Sachs,
Harout DerSimonian
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199708150-00021
Subject(s) - antibody , xenotransplantation , bovine serum albumin , transplantation , microbiology and biotechnology , biology , chemistry , immunology , medicine
The cell surface carbohydrate moiety, Gal(alpha1,3)Galactose (alphaGal), has been implicated as the major determinant recognized by more than 80% of human anti-porcine natural antibodies (NAb). An ELISA system was developed for the detection of this subpopulation of porcine cell-reactive NAb using synthetic alphaGal conjugated to bovine serum albumin.