Open AccessEFFECT OF CILASTATIN ON CYCLOSPORINE-INDUCED ACUTE NEPHROTOXICITY IN KIDNEY TRANSPLANT RECIPIENTS
Author(s) -
Mario Carmellini,
Fabiana Frosini,
Franco Filipponi,
Ugo Boggi,
Franco Mosca
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199707150-00029
Subject(s) - medicine , nephrotoxicity , cilastatin , imipenem/cilastatin , urology , renal function , kidney transplantation , transplantation , creatinine , kidney , gastroenterology , surgery , imipenem , antibiotics , antibiotic resistance , microbiology and biotechnology , biology
Cyclosporine (CsA)-induced acute nephrotoxicity could be reduced by prevention of parenchymal accumulation of the drug itself. The objective of this prospective study was to evaluate whether cilastatin, an inhibitor of active tubular resorption of CsA, reduces CsA-induced acute nephrotoxicity in kidney graft recipients.