Open AccessRECURRENT TYPE III MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS AFTER KIDNEY TRANSPLANTATION
Author(s) -
José Morales,
Miriam Martínez,
Eduardo Bustillo,
María Teresa Múñoz,
Raquel Gota,
Gabriel Usera
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199704270-00022
Subject(s) - membranoproliferative glomerulonephritis , lamina densa , medicine , transplantation , mesangium , kidney transplantation , pathology , glomerular basement membrane , nephrotic syndrome , glomerulonephritis , biopsy , renal biopsy , hemodialysis , kidney , basement membrane , surgery
The first well-documented case of recurrent type III membranoproliferative glomerulonephritis after kidney transplantation is reported in this article. A 48-year-old man was admitted to the hospital because of nephrotic syndrome and moderate renal failure. The renal biopsy showed double-contour images at light microscopy. Electron microscopy revealed electron-dense deposits in the mesangium and in both the subepithelial and subendothelial sides of the basement membrane. Subepithelial deposits were sometimes hump-like and produced an irregular disruption of the lamina densa. A diagnosis of type III membranoproliferative glomerulonephritis was suggested. The patient had a rapid decrease in renal function and received dialysis in 3 months. Three years later, he received a cadaveric kidney transplant, and subsequently recovered normal renal function. Proteinuria appeared after 13 months, and a biopsy of the graft demonstrated recurrence of the original disease. Seven years after transplantation, he returned to hemodialysis.