Open AccessANTIAPOPTOTIC COMPOUND TO ENHANCE HYPOTHERMIC LIVER PRESERVATION1
Author(s) -
Guanghan Wu,
Licia Tomei,
Ian C. Bathurst,
F. Zhang,
C. B. Hong,
C. J. Issel,
Amedeo Columbano,
Robert K. Salley,
Sufan Chien
Publication year - 1997
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199703270-00003
Subject(s) - lactate dehydrogenase , liver function , liver transplantation , viaspan , creatine kinase , medicine , apoptosis , cold storage , endocrinology , transplantation , biology , enzyme , biochemistry , horticulture
Apoptosis (programmed cell death) occurs as a consequence of global organ ischemia during isolation and storage prior to transplantation. If apoptosis is inhibited during ischemia, organ preservation should be improved, and the length of time for permissible storage may be increased. The objective of this study was to test the effect of a newly developed antiapoptotic compound, LXR-015, during extended hypothermic liver preservation.