Open AccessFN18-CRM9 IMMUNOTOXIN PROMOTES TOLERANCE IN PRIMATE RENAL ALLOGRAFTS1
Author(s) -
Stuart J. Knechtle,
Daniel Vargo,
John H. Fechner,
Yuan Zhai,
Jue Wang,
Michael J. Hanaway,
Joshua Scharff,
Huaizhong Hu,
Leslie A. Knapp,
David I. Watkins,
David M. Neville
Publication year - 1997
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199701150-00002
Subject(s) - immunotoxin , saporin , immunology , transplantation , medicine , potency , immune tolerance , major histocompatibility complex , t cell , biology , in vitro , immune system , antibody , monoclonal antibody , biochemistry
Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potency, was evaluated in a transplant model.