Open AccessHISTOCOMPATIBILITY TESTING OF DOG FAMILIES WITH HIGHLY POLYMORPHIC MICROSATELLITE MARKERS1
Author(s) -
John L. Wagner,
Robert Burnett,
Susan DeRose,
Leigh V. Francisco,
Rainer Storb,
Elaine A. Ostrander
Publication year - 1996
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199609270-00032
Subject(s) - microsatellite , pedigree chart , histocompatibility testing , biology , typing , histocompatibility , major histocompatibility complex , human leukocyte antigen , allele , genetics , transplantation , antigen , gene , medicine , surgery
The dog has served traditionally as a model for marrow and organ transplantation. A key component of any study of transplantation is histocompatibility typing of donors and recipients. Towards the development of a less expensive, more simplified typing system within canine families, a new highly polymorphic microsatellite marker for the canine Major Histocompatibility Complex class II region was isolated and characterized. In addition, we report on the application of class I and class II microsatellite-based markers for following the inheritance of the alleles within the canine analog of the human HLA loci, DLA, through multi-generation pedigree.