Open AccessMAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION AND CROSS-PRIMING OF H-Y ANTIGEN IN RATS
Author(s) -
HongDuo Chen,
Willys K. Silvers
Publication year - 1991
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-199101000-00043
Subject(s) - major histocompatibility complex , priming (agriculture) , immunology , histocompatibility , antigen , biology , mhc restriction , mhc class i , human leukocyte antigen , botany , germination
Although female rats can be sensitized to H-Y-incompatible male skin isografts following exposure to MHC-incompatible male lymphoid cells, these cells are not as effective as MHC-compatible male cells. Evidence is presented that the effectiveness of the MHC-incompatible cells is a consequence of crosspriming and that such crosspriming only occurs if these cells are rejected.