Open AccessCHOLESTATIC EFFECT OF CYCLOSPORINE IN THE RAT AN INHIBITION OF BILE ACID SECRETION
Author(s) -
Le Thai B,
M Dumont,
A Michel,
Serge Erlinger,
Didier Houssin
Publication year - 1988
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198810000-00008
Subject(s) - cholestasis , bile acid , medicine , secretion , endocrinology , chemistry , pharmacology
Cyclosporine administration in patients with organ transplants may cause cholestasis. In the rat, intraperitoneal administration of cyclosporine, 10 mg/kg, for three weeks did not cause liver function test abnormalities or hepatic histological lesions. However a significant reduction of bile flow and bile acid secretion rates was observed. The fact that reduction of bile flow was related to a decrease of the bile acid-independent flow suggests that cyclosporine-induced cholestasis results from an inhibition of bile acid secretion. Whether this inhibition is caused by the parental molecule or by cyclosporine metabolites needs to be clarified.