Open AccessSTRATEGIES OF MONOCLONAL ANTIBODY THERAPY THAT INDUCE PERMANENT TOLERANCE OF ORGAN TRANSPLANTS
Author(s) -
Jeffrey Herbert,
Bruce Roser
Publication year - 1988
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198808001-00024
Subject(s) - monoclonal antibody , medicine , immune tolerance , in vivo , immunology , transplantation , antibody , monoclonal , graft rejection , major histocompatibility complex , antigen , biology , microbiology and biotechnology
Treatment of normal rats with certain monoclonal anti-CD4 antibodies, beginning on the day of grafting, prevents heart graft rejection across a full MHC-haplotype mismatch. Adequate doses of antibody MRC OX-35, which is very potent in vivo, led to the induction of authentic specific tolerance of the transplants. In the very stringent grafting test of transplantation of DA skin to high-responder LOU recipients, adjunctive therapy with cyclosporine, in addition to the anti-CD4 antibodies, is required to induce tolerance. Since tolerance persists indefinitely after a 30-day course of treatment and appears to involve T cell-mediated suppression, this form of treatment is of potential clinical interest.