Open AccessCYTOMEGALOVIRUS INFECTION COMPLICATING RENAL TRANSPLANTATION AND ITS RELATIONSHIP TO ACUTE TRANSPLANT GLOMERULOPATHY
Author(s) -
Neil Boyce,
Kathleen Hayes,
David L. Gee,
S R Holdsworth,
Napier M. Thomson,
D F Scott,
Robert C. Atkins
Publication year - 1988
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198804000-00008
Subject(s) - medicine , transplantation , cytomegalovirus , incidence (geometry) , gastroenterology , betaherpesvirinae , immunology , azathioprine , prednisolone , ganciclovir , serology , kidney transplantation , complication , human cytomegalovirus , herpesviridae , viral disease , antibody , virus , disease , physics , optics
The incidence of cytomegalovirus (CMV) infection was established, using laboratory criteria, in 298 patients receiving 362 renal allografts (164/298 = 55%). The incidence of CMV infection did not differ between azathioprine/prednisolone-treated and cyclosporine-treated patients (55% vs. 57% NS). The use of antithymocyte globulin (ATG) increased the incidence of CMV infection (78% vs. 51%: P less than 0.01). Donor and recipient CMV status, known for 116 allografts, did not correlate with the incidence of CMV infection (recipient CMV-positive = 50%; recipient CMV-negative = 54%: NS). CMV infection was responsible for 8 patients' deaths (2.7% mortality). Thirty-three patients with acute transplant glomerulopathy were identified (11%). There was no correlation between acute transplant glomerulopathy and CMV infection. Glomerulopathy was associated with poor graft survival (22/33 patients with a graft survival of less than 6 months). Thus CMV infection, although a common complication of renal transplantation with significant morbidity and mortality, is not closely associated with acute transplant glomerulopathy. Further, the lack of correlation of donor-recipient CMV serologic status with graft outcome limits the usefulness of pretransplantation donor screening.