Open AccessERYTHROCYTE REPOPULATION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION ANALYSIS USING ERYTHROCYTE ANTIGENS
Author(s) -
B.A. van Dijk,
Alice Drenthe-Schonk,
A. Bloo,
V.A.J.M. Kunst,
J Janssen,
T.J.M. de Witte
Publication year - 1987
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198711000-00011
Subject(s) - medicine , bone marrow , serology , immunology , transplantation , leukemia , antigen , histocompatibility , human leukocyte antigen , bone marrow transplantation , blood transfusion , histocompatibility testing , antibody
Blood samples from 31 of 50 consecutive patients receiving bone marrow from an HLA-identical and mixed lymphocyte culture-nonreactive sibling were investigated for the presence of donor and autologous erythrocytes. Simple serological techniques using antigenic differences between donor and recipient and a blood transfusion policy taking these differences into account made this study possible. A total of 71% of the patients had donor erythrocytes demonstrable 4 weeks after bone marrow transplantation; almost all patients did so after 2 months. Disappearance or absence of donor red cells indicated poor patient prognosis. Persistence or reappearance of autologous erythrocytes in small percentages (0.05-10%) occurred without relapse of leukemia. Reappearance in high percentage (50-100%) indicated relapse.