Open AccessVARIABLES PREDICTING BACTERIAL AND FUNGAL INFECTIONS AFTER ALLOGENEIC MARROW ENGRAFTMENT
Author(s) -
Thomas Paulin,
Olle Ringdén,
Björn M. Nilsson,
B Lönnqvist,
Gösta Gahrton
Publication year - 1987
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198703000-00015
Subject(s) - medicine , incidence (geometry) , leukemia , transplantation , splenectomy , immunology , cytomegalovirus , disease , gastroenterology , viral disease , spleen , herpesviridae , virus , physics , optics
Sixty-seven consecutive patients with aplastic anemia or leukemia who had been treated by allogeneic marrow transplantation and had survived for more than 1 month were surveyed in order to determine the incidence of nonviral infections occurring from 1 month to 3 years after transplantation. Twenty-eight of the 67 patients had one or more infections during this period. Around 20% suffered from pulmonary infections and 20% were classified as having a systemic infection. Ten patients died of bacterial or fungal infection, of whom 6 had graft-versus-host disease. In multivariate analyses acute graft-versus-host disease (P less than 0.0009), splenectomy (P less than 0.02), cytomegalovirus infection (P less than 0.05), and a low marrow cell dose (P less than 0.07) were correlated with nonviral infections.