Open AccessLACK OF DONOR-SPECIFIC TOLERANCE IN MICE WITH ESTABLISHED ANTI-Ia-TREATED ISLET ALLOGRAFTS12
Author(s) -
Charles E. Morrow,
David E.R. Sutherland,
Michael W. Steffes,
John S. Najarían,
Fritz H. Bach
Publication year - 1983
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198336060-00021
Subject(s) - islet , renal capsule , streptozotocin , antigen , monoclonal antibody , in vitro , antibody , transplantation , medicine , capsule , immunology , endocrinology , diabetes mellitus , biology , biochemistry , botany
Pancreatic islet allografts pretreated in vitro with monoclonal Ia antibody and transplanted beneath the renal capsule result in normoglycemia beyond 100 days in streptozotocin-induced diabetic recipient mice that differ only at H-2 K, H-2 K + I, or H-2 K + I + D from the donors. Mice with established islet allografts are not tolerant of donor-specific skin or islet antigens, but rather reject donor skin grafts in an accelerated fashion. Established anti-Ia antibody pretreated islet allografts continue to express target antigens and remain susceptible to rejection after challenge with donor skin grafts.