Open AccessIMPORTANCE OF HLA-DR MATCHING IN POLYTRANSFUSED CADAVERIC KIDNEY TRANSPLANT RECIPIENTS
Author(s) -
Yves Vanrenterghem,
Ignace Vandeputte,
T. Lerut,
L Roels,
Gruwez Ja,
Paul Michielsen
Publication year - 1983
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198310000-00007
Subject(s) - human leukocyte antigen , medicine , cadaveric spasm , kidney transplantation , transplantation , surgery , kidney , matching (statistics) , histocompatibility testing , typing , prospective cohort study , immunology , pathology , antigen , biology , genetics
Since August 1978 prospective HLA-DR typing has been performed in 157 donor-recipient pairs. All recipients received pretransplant blood transfusions. This study shows that HLA-DR matching can significantly improve the survival of cadaveric kidney allografts, even in polytransfused recipients. Patients receiving kidneys with no HLA-DR incompatibilities have a one-year graft survival of 97%, versus 86% for recipients with 1 HLA-DR incompatibility and 73% for recipients with 2 HLA-DR incompatibilities. The cumulative dose of corticosteroids during the first year after transplantation is significantly lower in patients with no DR-incompatibilities. HLA-A and B matching have no additional effect on graft survival.