Open AccessEVIDENCE THAT STRONG Mls DETERMINANTS ARE NONPOLYMORPHIC1
Author(s) -
Molnar-Kimber Kl,
Jonathan Sprent
Publication year - 1981
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198105010-00014
Subject(s) - locus (genetics) , allele , gene , biology , genetics , lymphocyte , mixed lymphocyte reaction , microbiology and biotechnology , t cell , immune system
Gene products of the murine Mls locus elicit high primary mixed lymphocyte reactions (MLRs). Although this locus is considered to have four alleles, only two of these alleles, i.e., Mlsa and Mlsd, give strong responses in primary MLRs. This paper presents a series of experiments to show that Mlsa and Mlsd are in fact antigenically indistinguishable. Strong Mls determinants thus appear to be nonpolymorphic.