Open AccessINCREASED INCIDENCE OF IgM CLASS SMOOTH MUSCLE ANTIBODY IN PATIENTS AFTER RENAL TRANSPLANTATION1
Author(s) -
D. Middleton,
S A McMillan,
Margaret Haire,
John Douglas,
Mary G. McGeown
Publication year - 1981
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-198105010-00008
Subject(s) - transplantation , medicine , sma* , autoantibody , antibody , incidence (geometry) , hemodialysis , titer , gastroenterology , kidney transplantation , immunology , physics , mathematics , combinatorics , optics
Autoantibodies were examined in 70 patients with renal failure, before acceptance on a hemodialysis program, during the program, and up to 3 months after renal transplantation. Smooth muscle antibody (SMA) in the IgM class was detected in 76% of the patients after transplantation compared with 14% before transplantation. This increase was significant at the 5% level. Furthermore, two groups of patients were distinguished on the basis of a 4-fold or greater increase or no demonstrable increase in the titer of IgM SMA after transplantation. Rejection episodes occurred more frequently amongst patients from this former group (67%) compared with the latter group (35%).