Open AccessRELATIONSHIP OF B CELL ALLOANTIBODIES TO RENAL ALLOGRAFT SURVIVAL
Author(s) -
T. Mohanakumar,
Giedlin Ma,
Rhodes Cl,
DuVall Ch,
G Méndez-Picón,
Kaplan Am,
Lee Hm
Publication year - 1979
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-197904000-00014
Subject(s) - transplantation , antibody , cytotoxic t cell , medicine , immunology , b cell , isoantibodies , kidney transplantation , lymphocyte , kidney , biology , in vitro , biochemistry
To define the relationship of donor-specific B lymphocyte alloantibodies to renal allograft survival, longitudinal serum samples obtained pre- and post-transplantation were examined for antibodies cytotoxic to donor B lymphocytes. Ten of 17 renal allograft recipients had antibodies to donor B lymphocytes but not T lymphocytes either pre- and/or post-transplantation. Three patients underwent successful transplants despite preformed B cell antibodies; however, seven who developed B cell antibodies only after transplantation are either undergoing chronic rejection (4) or have had severe rejection crisis (3). Seven patients with no B cell antibodies have functioning grafts. In all cases, B cell antibodies were detected before biochemical and clinical evidence of rejection. Similar findings were noted when sera of 38 renal transplant recipients were examined for B cell antibodies cytotoxic to an unrelated panel of B lymphocytes. These results demonstrate that the development of B cell alloantibodies after transplantation is often associated with rejection and that successful renal transplantation can be performed across a positive B cell crossmatch.