Open AccessREMOVAL OF MYELOTOXICITY FROM ANTILYMPHOCYTIC SERA
Author(s) -
M. Y. Gordon,
Heddy Zola
Publication year - 1979
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-197902000-00008
Subject(s) - medicine , antigen , bone marrow , immunology , bone marrow transplantation , transplantation , in vitro , biology , biochemistry
Antilymphocyte sera (ALS) were prepared by different methods and examined for their myelotoxicity by bone marrow colony-forming assay, both before and after absorption with B cell antigens. The results show that myelotoxicity can readily be removed from some, but not all, ALS. The source of antigen and the immunisation protocol used determine the degree of myelotoxicity and hence the number of absorptions required. Non-myelotoxic ALS may be suitable for the prevention of graft-versus-host disease (GVHD) by in vitro treatment of bone marrow before transplantation.