Open AccessHUMORAL ANTIBODY RESPONSES FOLLOWING TRANSPLANTATION IN MAN
Author(s) -
Marion Waller,
James C. Pierce,
Hyung M. Lee,
Harold J. Levinson
Publication year - 1975
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-197503000-00003
Subject(s) - antibody , immunology , titer , transplantation , medicine , humoral immunity , immune system , isoantibodies , antibody titer , graft rejection , surgery
Sequential titers of five different humoral antibodies (antirat erythrocyte, antisheep erythrocyte, isoantibodies, rheumatoid factors, and serum agglutinators) were simultaneously performed on 20 patients with renal transplants, 12 patients with skin transplants, and 2 patient populations (one hospitalized and one ambulatory). The results suggested that rises in titer of any of these antibodies could not be used as an indicator of acute rejection. Nevertheless, patients who lacked rejection episodes were unlikely to show humoral responses and always lacked antiglobulin responses. Heterophil responses always preceeded antiglobulin responses. These results suggest that heterophils are cross reacting antibodies and antiglobulins are auxillary immune responses.