Open AccessThe Fate of Calvarias Implanted into the Epidural Spaces of Rats A Preliminary Study
Author(s) -
Haruo Oura,
Toru Tamaki,
Munehito Yoshida,
Shinichi Matsuura,
Muneharu Ando,
K Shima
Publication year - 1992
Publication title -
spine (philadelphia, pa. 1976)/spine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.657
H-Index - 254
eISSN - 1528-1159
pISSN - 0362-2436
DOI - 10.1097/00007632-199203001-00004
Subject(s) - medicine , ossification , bone formation , epidural space , spinal canal , surgery , anatomy , mesenchymal stem cell , trabecular bone , spinal cord , pathology , osteoporosis , psychiatry
The histologic changes occurring in newborn rat calvarias implanted into the epidural space of adult rats were observed to determine whether this method was adequate as an experimental model of new bone formation in the spinal canal. Two weeks after implantation, all implanted calvarias of newborn rats grew with ossification in the epidural space. The grafted calvarias continued to grow gradually 6 weeks after this procedure. Six months later, 40% of the grafted calvarias showed progressive bone formation with osteoblasts, chondrocytes, and immature mesenchymal cells. In the other 60%, the implanted calvarias had developed into mature trabecular bone. Twelve months after the procedure, the calvarias had developed into mature bone in all cases, although the size of the grafted calvarias tended to decrease in size. It was concluded that this experiment had devised a suitable model for understanding the process of new bone formation in the spinal canal.