Open AccessTreatment of Infection Due to Penicillinase-producing Neisseria gonorrhoeae with Oral Thiamphenicol and with Oral Lymecycline
Author(s) -
Ahmed S. Latif,
Evaristo Marowa,
Peter R. Mason,
Joseph Sithole,
John Tambo,
FELlX Dhamu,
EMlLY Paraiwa
Publication year - 1986
Publication title -
sexually transmitted diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 105
eISSN - 1537-4521
pISSN - 0148-5717
DOI - 10.1097/00007435-198607000-00008
Subject(s) - thiamphenicol , medicine , neisseria gonorrhoeae , gonorrhea , microbiology and biotechnology , neisseriaceae , neisseria , virology , antibiotics , chloramphenicol , bacteria , biology , human immunodeficiency virus (hiv) , genetics
Seventy-five men with gonococcal urethritis were treated with a single oral dose of thiamphenicol, and 88 men with this infection were treated with two 1.5-g oral doses of lymecycline taken 12 hr apart. Of the 75 subjects treated with thiamphenicol, 72 (96%) were cured, as compared with 80 (91%) treated with lymecycline. Sixty subjects (37%) were infected with penicillinase-producing Neisseria gonorrhoeae. In this group, 28 (97%) of 29 subjects treated with thiamphenicol were cured, as compared with 29 (94%) of 31 subjects treated with lymecycline. Patient compliance with the two-dose regimen was excellent, and no adverse effects occurred with either drug. Lymecycline may therefore be an effective alternative to thiamphenicol in those countries where strains of N. gonorrhoeae remain sensitive to the tetracyclines.