Open AccessA Comparison of Rosoxacin with Ampicillin and Probenecid in the Treatment of Uncomplicated Gonorrhea
Author(s) -
Alan Cohen,
Michael F. Rein,
Robert C. Noble
Publication year - 1984
Publication title -
sexually transmitted diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 105
eISSN - 1537-4521
pISSN - 0148-5717
DOI - 10.1097/00007435-198401000-00005
Subject(s) - medicine , probenecid , ampicillin , gonorrhea , regimen , antibiotics , neisseria gonorrhoeae , headaches , diarrhea , gastroenterology , surgery , immunology , microbiology and biotechnology , human immunodeficiency virus (hiv) , biology
Rosoxacin, a beta-lactamase-resistant, pyridyl quinolone derivative with in vitro activity against Neisseria gonorrhoeae, was compared to an oral regimen of ampicillin plus probenecid for the treatment of uncomplicated gonococcal infection. Fifty-seven patients were evaluated for the effectiveness of the two antibiotics. Thirty (97%) of 31 patients receiving rosoxacin were cured of their infection as were 25 (96%) of 26 patients who received the oral regimen of ampicillin plus probenecid. Both drug regimens were associated with a significant number of side effects. Of the ampicillin-treated group, 29% had diarrhea and/or abdominal cramping. Of the rosoxacin-treated patients, 52% had reactions classified as central nervous system effects; these included headaches, dizziness, euphoria, and drowsiness.