Open AccessOne Gram of Cefoxitin Cures Uncomplicated Gonococcal Urethritis Caused by Penicillinase-producing Neisseria gonorrhoeae (PPNG)
Author(s) -
Sánchez de la Muela Pl,
Wignall Fs,
Zajdowicz Tr,
Sharon Kerbs,
Berg Sw,
Harrison Wo
Publication year - 1983
Publication title -
sexually transmitted diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 105
eISSN - 1537-4521
pISSN - 0148-5717
DOI - 10.1097/00007435-198307000-00007
Subject(s) - neisseria gonorrhoeae , cefoxitin , gonorrhea , medicine , probenecid , penicillin , regimen , microbiology and biotechnology , antibiotics , urethritis , sexually transmitted disease , gastroenterology , syphilis , virology , staphylococcus aureus , bacteria , biology , genetics , human immunodeficiency virus (hiv)
Therapy of disease caused by penicillinase-producing Neisseria gonorrhoeae with lower-than-standard doses of cefoxitin was evaluated. A pilot study showed that doses of greater than or equal to 1 g were adequate, whereas 500-mg doses consistently failed. After the pilot study, 89 men with gonorrhea were treated with 1 g of cefoxitin given intramuscularly plus 1 g of probenecid given orally. Of the 89 men, 86 were cured. Sixty per cent were infected with penicillin-resistant strains of N. gonorrhoeae. The three men who were culture-positive on follow-up had been sexually reexposed, whereas none of those with negative cultures had had reexposure. These clinical results indicate that a treatment regimen of 1 g of parenteral cefoxitin plus 1 g of oral probenecid appears to be as effective as the standard 2-g dose. Regimens using doses lower than 1 g are ineffective.