Open AccessREOVIRUS TYPE 2 ISOLATED FROM CEREBROSPINAL FLUID
Author(s) -
Laura Hermann,
Joanne Embreé,
Paul R. Hazelton,
Barbara Wells,
Kevin M. Coombs
Publication year - 2004
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/00006454-200404000-00026
Subject(s) - cerebrospinal fluid , serotype , virology , hypoalbuminemia , diarrhea , virus , microbiology and biotechnology , pathogen , sepsis , meningitis , biology , medicine , immunology , pathology , psychiatry
An 8-week-old female infant presented with a history of active varicella complicated by Escherichia coli sepsis, oral thrush, hypoalbuminemia, intermittent fevers, diarrhea and feeding intolerance. Rhesus monkey kidney cells inoculated with cerebrospinal fluid revealed reovirus-like particles by electron microscopy. Virus neutralization and RNA-gel electrophoresis studies identified the isolated pathogen as reovirus serotype 2. This report represents one of only a few to isolate reovirus from the central nervous system in humans.