Open AccessHerpes simplex virus colitis in a neonate
Author(s) -
Andrew J Daley,
P. D. Craven,
A.J.A. Holland,
Cheryl Jones,
Nadia Badawi,
David Isaacs
Publication year - 2002
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/00006454-200209000-00025
Subject(s) - medicine , hematochezia , colitis , herpes simplex virus , perforation , gastrointestinal tract , herpesviridae , polymerase chain reaction , pathology , alphaherpesvirinae , virology , virus , sigmoid colon , viral disease , immunology , gastroenterology , colonoscopy , rectum , biology , colorectal cancer , cancer , biochemistry , punching , materials science , gene , metallurgy
Involvement of the gastrointestinal tract in neonates with congenital herpes simplex virus (HSV) infection is rarely described. We report a case of a newborn with disseminated HSV infection associated with profuse hematochezia and late sigmoid colon perforation. Histologic examination showed patchy areas of ulceration with multinucleated giant cells and HSV nucleic acid was detected by polymerase chain reaction in colonic tissue. No clinically apparent episodes of recurrent colitis occurred in the first year of life.