Open AccessFATAL DISSEMINATED CANDIDA LUSITANIAE INFECTION IN AN INFANT WITH CHRONIC GRANULOMATOUS DISEASE
Author(s) -
Ofer Levy,
JeanPierre Bourquin,
Alisa McQueen,
Alan B. Cantor,
Catherine S. Lachenauer,
Richard Malley
Publication year - 2002
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/00006454-200203000-00023
Subject(s) - hepatosplenomegaly , chronic granulomatous disease , medicine , antifungal , amphotericin b , broad spectrum , budding yeast , pathology , disease , immunology , dermatology , biology , yeast , chemistry , genetics , combinatorial chemistry , saccharomyces cerevisiae
A 3-month-old boy born to a mother carrying an X-linked form of chronic granulomatous disease presented with persistent fever and hepatosplenomegaly. The diagnosis was confirmed as a gp91phox defect by genetic analysis, and the patient was managed with broad spectrum antibacterial agents, gamma-interferon and later amphotericin B. A liver biopsy revealed granulomata with budding yeast forms, and cultures of blood and urine grew Candida lusitaniae. The patient died 26 days after admission.