Open AccessGLOMERULONEPHRITIS AFTER RECOMBINANT HEPATITIS B VACCINE
Author(s) -
Marco Pennesi,
Giuliano Torre,
Manuela Del Santo,
Aurelio Sonzogni
Publication year - 2002
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/00006454-200202000-00020
Subject(s) - medicine , glomerulonephritis , vaccination , hepatitis , immunology , monoclonal antibody , kidney disease , renal biopsy , hepatitis b , hepatitis b vaccine , virology , biopsy , antibody , pathology , kidney , hepatitis b virus , virus , hbsag
Renal complications after vaccination with hepatitis B recombinant vaccine are rare; very few cases are reported without a histopathologic definition. We describe a case of glomerulonephritis in a 12-year-old girl, beginning after the inoculation of hepatitis B vaccine. The immunohistochemical examination of her renal biopsy, with the use of monoclonal antibodies, shows the presence of hepatitis B surface antigen in renal tissue. After 2 years chronic glomerulonephritis persisted and was treated with angiotensin-converting enzyme inhibitors. After 3 years of follow-up, the renal disease was in remission, and treatment was stopped.