Open AccessACOG Practice Bulletin #64: Hemoglobinpathies in Pregnancy
Publication year - 2005
Publication title -
obstetrics and gynecology (new york. 1953. online)/obstetrics and gynecology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.664
H-Index - 220
eISSN - 1873-233X
pISSN - 0029-7844
DOI - 10.1097/00006250-200507000-00052
Subject(s) - medicine , thalassemia , hemoglobinopathy , pregnancy , heterozygote advantage , compound heterozygosity , hemoglobin , pediatrics , obstetrics , hemolytic anemia , genetics , gene , genotype , allele , biology
The hemoglobinopathies are a heterogeneous group of single-gene disorders that include the structural hemoglobin variants and the thalassemias. More than 270 million people worldwide are heterozygous carriers of hereditary disorders of hemoglobin, and at least 300,000 affected homozygotes or compound heterozygotes are born each year (1). The purpose of this document is to review the most common hemoglobinopathies and to provide recommendations for the screening and clinical management of hemoglobinopathies during pregnancy.