Open AccessGrowth hormone responses during strenuous exercise: the role of GH-releasing hormone and GH-releasing peptide-2
Author(s) -
Maas Hcm,
de Vries Wr,
I. Maitimu,
Bol E,
Bowers Cy,
Koppeschaar Hp
Publication year - 2000
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1097/00005768-200007000-00007
Subject(s) - medicine , endocrinology , ex vivo , hormone , cycle ergometer , growth hormone , growth hormone–releasing hormone , chemistry , blood pressure , heart rate , biochemistry , in vitro
This study was designed to investigate the role of two effective releasers of growth hormone (GH): GHRH and GHRP-2 during exercise (EX). Eight healthy male subjects (ages: 22 +/- 1.2 (mean +/- SD) yr, BMI: 22.5 +/- 2.2 kg x m(-2)) were exposed to maximally stimulating dose of 100 microg GHRH iv, and 200 microg GHRP-2 iv, during incremental EX on a cycle ergometer to exhaustion. GH responses after EX alone were compared with the responses after the combined administration of the same EX plus GHRH, EX plus GHRP-2, and EX plus GHRH plus GHRP-2. Blood samples were obtained in the fasted state at intervals for 2 h postexercise and the area under the GH response curve (AUC) was calculated by trapezoidal integration.