Open AccessInhibition of histamine release by nedocromil sodium reduces exercise-induced hypoxemia in master athletes
Author(s) -
Christian Préfaut,
F Anselme-Poujol,
Corinne Caillaud
Publication year - 1997
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1097/00005768-199701000-00003
Subject(s) - nedocromil sodium , hypoxemia , placebo , histamine , exercise induced asthma , medicine , athletes , anesthesia , endocrinology , asthma , physical therapy , alternative medicine , pathology
During exercise in highly-trained older master athletes (MA), the impairment of pulmonary gas exchanges has been shown to be associated with a concomitant increase in histamine release (2). To determine the role of the histamine released (% H) during exercise-induced hypoxemia, seven MA (age 63.2 yr +/- 1.9), all of whom were known to develop exercise-induced hypoxemia, performed two maximal incremental exercise tests at a one-month interval after administration of nedocromil sodium (which inhibits histamine and other mediator release) or placebo in random double-blind order. During exercise testing, blood samples for arterial blood gas analysis and histamine assay were drawn at rest, exercise and recovery. Nedocromil sodium induced an inhibition in % H (0.57 +/- 0.03 at maximal load (Pmax) with placebo vs 0.24 +/- 0.02 with nedocromil sodium) linked with an improvement of pulmonary gas exchange (PaO2: 71.1 +/- 1.4 at Pmax with placebo vs 83.4 +/- 3 with nedocromil sodium; D(Ai-a)O2: 37.5 +/- 1.4 at Pmax vs 19.1 +/- 3.1, respectively). These results confirm the link established between the increase in histamine and exercise-induced hypoxemia in master athletes.