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Increased Expression of Laminin‐5 and Its Prognostic Significance in Hypopharyngeal Cancer
Author(s) -
Nakayama Meijin,
Sato Yuichi,
Okamoto Makito,
Hirohashi Setsuo
Publication year - 2004
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-200407000-00022
Subject(s) - hypopharyngeal cancer , medicine , pathology , immunohistochemistry , h&e stain , perineural invasion , cancer , laminin , vascular invasion , oncology , biology , cell , genetics
Objectives: We investigated the clinicopathologic significance of laminin‐5 γ2 chain (LNγ2) expression in 26 surgically removed hypopharyngeal cancers and compared the results with conventional prognostic factors elicited from hematoxylin‐eosin (H&E) stained whole‐mount laryngeal sections. Study Design: Stainability of LNγ2 was mainly evaluated at the invasive front of the cancer nests. Scoring was performed on the basis of a semiquantitative scale defined according to the number of immunopositive cancer cells (score 3, 2, 1, and 0). Stainability of LNγ2 was also evaluated macroscopically at different tumor locations such as surface center, interstitial space, and invasive front. Status of cartilage and vascular invasion and patterns of tumor extension were evaluated from H&E stained sections. The results of LNγ2 expression correlated with the tumor stages, neck node status, pathologic differentiation, and prognoses. Results: Among the 26 cases, 24 demonstrated positive LNγ2 expression. Of these cases, 1, 14, 9, and 0 showed scores of 3, 2, 1, and 0, respectively. Positive expression of LNγ2 at the invasive front was more prominent in the high‐expression group, and surface center was often positive in the cases of low‐expression group. Among the H&E stained prognostic factors, vascular invasion and infiltrative pattern demonstrated significant correlations with clinical outcome. Vascular invasion and infiltrative pattern were also closely related to positive LNγ2 expression. Five‐year survival rates of patients who showed high LNγ2 expression were significantly poorer than in patients with low expression. Conclusion: Hypopharyngeal cancers positive for LNγ2 indicate a considerable risk for cancer progression and are closely related to prognosis. Increased LNγ2 expression might be a prognostic indicator for squamous cell carcinomas of the hypopharynx.