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Chemokine RANTES Promoter Polymorphisms in Allergic Rhinitis
Author(s) -
Kim Jeong Joong,
Lee Jung Hun,
Jang Chul Ho,
Kim Yong Shin,
Chae Soo Cheon,
Chung Hun Taeg,
Choi Tae Wook,
Lee Jae Hoon
Publication year - 2004
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-200404000-00013
Subject(s) - genotyping , immunology , allele , chemokine , promoter , polymerase chain reaction , genotype , allele frequency , gene , medicine , biology , genetics , gene expression , inflammation
Objectives/Hypothesis RANTES is one of the most widely studied of the chemokines linked to allergic diseases. Two polymorphisms of the RANTES promoter region (–403 G/A and –28 C/G) have been found. The authors investigated whether these RANTES promoter polymorphisms were associated with allergic rhinitis. Study Design Case‐control study. Methods Blood samples for genetic analysis were obtained from 151 individuals with allergic rhinitis and from 278 healthy individuals without atopic disease. Polymerase chain reaction–based assays for detection of the –403 G/A and –28 C/G polymorphisms of the RANTES gene were used for genotyping. Results The frequencies of both the RANTES –403A and –28G alleles were significantly higher in patients with allergic rhinitis than in control subjects ( P < .05 for both). Conclusion The study results indicated that the –403 and –28 alleles in the RANTES promoter region belong to the predictor gene set for allergic rhinitis and could be used in genomic analysis.