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Prognostic Value of Resection Margins in Supracricoid Laryngectomy
Author(s) -
Gallo Andrea,
Manciocco Valentina,
Tropiano Maria Luisa,
Simonelli Marilia,
Marvaso Vincenzo,
D'Arcangelo Enzo,
de Vincentiis Marco
Publication year - 2004
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-200404000-00005
Subject(s) - medicine , laryngectomy , larynx , resection , surgery , resection margin , retrospective cohort study , carcinoma , incidence (geometry) , basal cell , surgical margin , physics , optics
Objectives The objective was to assess the prognostic value of surgical margin involvement in patients treated for squamous cell carcinoma of the larynx. Study Design Retrospective study. Methods A review was made of 253 patients treated with supracricoid laryngectomy between 1984 and 2001. A histopathological study on the surgical resection margins was performed in all cases. The incidence of local recurrence was correlated with the histological features of resection margins. Results Forty patients (15.8%) were identified as having positive margins: 29 had invasive carcinoma and 11 had dysplastic lesions. The remaining 213 patients (84.2%) had negative margins. Subsequent follow‐up showed that 19 of 253 patients developed local recurrence and 3 patients developed regional recurrence. Nine of these patients had positive resection margins (six with invasive carcinoma and three with dysplastic lesions), and 10 had negative resection margins. Overall survival at 3 years was significantly higher for patients without recurrence than for patients with local or regional failure (89.9% vs. 45.5% [ P < .05]). Conclusion According to results of the study, patients with positive resection margins developed local recurrence more frequently than those with clear resection margins ( P < .05).