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Prothrombotic Factors in Children with Otitis Media and Sinus Thrombosis
Author(s) -
OestreicherKedem Yael,
Raveh Eyal,
Kornreich Liora,
Yaniv Isaac,
Tamary Hannah
Publication year - 2004
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-200401000-00015
Subject(s) - medicine , mastoiditis , thrombophilia , hydrosalpinx , thrombosis , pediatrics , abnormality , risk factor , complication , surgery , gastroenterology , otitis , pregnancy , genetics , infertility , biology , psychiatry
Objective Venous sinus thrombosis (VST) is the second most common intracranial complication of acute otitis media (AOM). There is some evidence that hereditary and acquired prothrombotic disorders are risk factors for VST. The aim of the present study was to evaluate whether children with AOM complicated VST have a prothrombotic tendency, which might have important therapeutic and preventive implications. Study Design Retrospective. Methods The files of children hospitalized at Schneider Children's Medical Center of Israel, a tertiary referral center, from 1999 to 2002, because of AOM complicated by acute mastoiditis and VST were reviewed. All children underwent laboratory work‐up for hypercoagulability. Results Seven children met the study criteria. Of these, five had prothrombotic disorders, namely elevated levels of lipoprotein apolipoprotein (Lp[a]) (n = 4), antibodies to beta 2‐glycoprotein and to cardiolipin (markers of antiphospholipid syndrome) (n = 4), and heterozygosity for factor V Leiden mutation (n = 1). One child had three abnormalities, two children had two abnormalities, and two children had one abnormality. Conclusions A prothrombotic tendency may exist in children with AOM complicated by mastoiditis and VST. Further studies are needed to evaluate its extent.