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Evidence Against Neonatal Aspiration of Keratinizing Epithelium as a Cause of Congenital Cholesteatoma
Author(s) -
BernalSprekelsen Manuel,
Sudhoff Holger,
Hildmann Henning
Publication year - 2003
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-200303000-00011
Subject(s) - cholesteatoma , epithelium , temporal bone , medicine , pathology , fetus , stratified squamous epithelium , middle ear , anatomy , pregnancy , biology , surgery , genetics
Objectives/Hypothesis It has been suggested that congenital cholesteatoma may be caused by perinatal aspiration of squamous epithelium. Study Design Microscopic study of fetal temporal bones. Methods Thirty‐one temporal bones from infants who died of sudden infant death syndrome before 1 year of age and 27 temporal bones obtained from preterm fetal deaths aged 4 to 8 months of fetal development were studied to assess signs of aspiration of squamous epithelium in the middle ear. Results None of the prenatal or postnatal temporal bones showed keratinizing epithelial cells or lanugo. A certain number of specimens displayed a nonspecific inflammatory lymphocytic infiltration. Conclusion The data in the present study do not support the theory of amniotic fluid and squamous epithelial aspiration as an origin of congenital cholesteatoma.