Premium
Gastroesophageal Reflux and Obstructive Sleep Apnea
Author(s) -
Senior Brent A.,
Khan Mumtaz,
Schwimmer Craig,
Rosenthal Leon,
Benninger Mike
Publication year - 2001
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-200112000-00012
Subject(s) - medicine , polysomnography , obstructive sleep apnea , reflux , ambulatory , gerd , respiratory disturbance index , apnea , population , sleep apnea , sleep study , prospective cohort study , sleep disorder , anesthesia , disease , insomnia , environmental health , psychiatry
Objective To determine the extent to which gastroesophageal reflux (GER)‐initiated laryngeal chemoreflexes contribute to obstructive sleep apnea (OSA). Methods Prospective, nonrandomized clinical trial of an antireflux treatment protocol as a means of reducing the severity of OSA. Population consisted of 10 males aged 20 to 64 years with confirmed OSA (by overnight polysomnography) and GER (by ambulatory pH probe monitoring). Patients were treated with omeprazole and standard antireflux protocol for 30 days and pre‐ and posttreatment polysomnography variables were compared. Results Mean apnea index declined 31% (45–31, P = .04); mean respiratory disturbance index declined 25% (62–46, P = .06). Three patients (30%) are “treatment responders” as defined by traditional OSA treatment definitions. Conclusions These results suggest a potential relationship between OSA and GER, the treatment of which may be an effective adjunctive in those with both disorders. Treatment of GER may significantly impact OSA in select individuals.