Premium
Use of Dexamethasone on the Prophylaxis of Nausea and Vomiting After Tympanomastoid Surgery
Author(s) -
Liu YunHou,
Li MinJia,
Wang PaChun,
Ho ShungTai,
Chang ChingFong,
Ho ChiuMing,
Wang JhiJoung
Publication year - 2001
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-200107000-00024
Subject(s) - medicine , dexamethasone , vomiting , anesthesia , nausea , postoperative nausea and vomiting , incidence (geometry) , placebo , surgery , saline , physics , alternative medicine , pathology , optics
Objective The aim of this study was to evaluate the prophylactic effect of dexamethasone on postoperative nausea and vomiting (PONV) in patients undergoing tympanomastoid surgery. Study Design Eighty patients (n = 40 in each of two groups) undergoing tympanomastoid surgery under general anesthesia were enrolled in this randomized, double‐blind, placebo‐controlled study. Methods After tracheal intubation, group 1 received 10 mg dexamethasone intravenously, whereas group 2 received saline intravenously. Several parameters concerning with the occurrence of PONV were evaluated. Results We found that dexamethasone reduced the total incidence of nausea and vomiting by 45%, with a 95% confidence interval of 26% to 64% ( P <.001). Furthermore, dexamethasone reduced the incidence of vomiting episodes >4 times and the incidence of patients requiring rescue antiemetics ( P <.05). Conclusion Dexamethasone at a dosage of 10 mg administered intravenously is effective in preventing PONV in patients undergoing tympanomastoid surgery.