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Repeated Inflation Does Not Prevent Otitis Media With Effusion in a Monkey Model
Author(s) -
Alper Cuneyt M.,
Doyle William J.
Publication year - 1999
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/00005537-199907000-00012
Subject(s) - medicine , eustachian tube , otitis , middle ear , effusion , tympanometry , surgery , anesthesia , audiology , audiometry , hearing loss
Objective : Investigate the efficacy of repeated middle ear inflation with an inert gas (argon) for preventing the development of middle ear effusion in monkeys with functional eustachian tube obstruction. Study Design : Prospective controlled trial of daily middle ear inflation with five monkeys assigned to the inflation group and four to the control group. Methods : The right tensor veli palatini muscle of nine monkeys was paralyzed with botulinum toxin. Tympanometry was done before the procedure and then daily for 21 days. Presence and distribution of effusion were assessed before paralysis and on day 15 using magnetic resonance imaging (MRI). In five right ears inflation was done beginning at the first observation of negative middle ear pressure of ≤−200 mm H 2 O and repeated on all days with pressures ≤−100 mm H 2 O. Four right ears served as uninflated controls. Results : Right middle ear pressure decreased in all animals over the course of the study. Pressure returned to near‐ambient levels immediately following the argon inflation but was decreased to control levels at the subsequent observation on the following day. MRI at day 15 documented effusion in all right ears with no quantifiable differences in amount or distribution between ears that were and were not inflated with argon. Conclusions : Repeated inflation with an inert gas does not prevent middle ear effusion in monkeys with functional eustachian tube obstruction.